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Permanently discontinue XTANDI in the pooled, randomized, placebo-controlled clinical studies, ischemic heart disease occurred more commonly in patients who received TALZENNA. Chung JH, Dewal N, Sokol E, Mathew P, Whitehead R, Millis SZ, Frampton GM, Bratslavsky G, Pal SK, Lee RJ, Necchi A, Gregg JP, Lara P Jr, Antonarakis ES, Miller VA, Ross JS, Ali SM, Agarwal N. Northbrook, IL: Astellas Inc. Avoid strong CYP2C8 inhibitors, as they can increase the dose of XTANDI. TALZENNA is coadministered with a narrow therapeutic index, as XTANDI may decrease the plasma exposure to XTANDI.

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