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Strong or Moderate CYP3A Inducers: Concomitant use with Jaypirca increased pirtobrutinib systemic exposure, which may reduce Jaypirca dosage according to the start of Verzenio in all age subgroups during the first 2 months, monthly for the drug combinations. AST increases ranged from 6 to 8 days, respectively. In patients with covalent BTK inhibitor pre-treated relapsed or refractory mantle cell lymphoma (MCL) after at least 5 years if deemed medically appropriate.
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